The Effects of Treadmill Exercise on Neurogenesis, Apoptosis and Neuroplasticity in Huntington's Disease Rat Model

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doi:2014.23.2.181

Exerc Sci > Volume 23(2); 2014 > Article

Exercise Science 2014;23(2): 181-191. doi: https://doi.org/10.15857/ksep.2014.23.2.181

트레드밀 운동이 헌팅턴병 유발 쥐의 뇌신경세포생성과 사멸 및 신경가소성에 미치는 영향

김유미¹, 김창주², 김태운², 지은상³, 서태범², 윤진환¹

¹한남대학교
²경희대학교
³상명대학교 체육학과

The Effects of Treadmill Exercise on Neurogenesis, Apoptosis and Neuroplasticity in Huntington's Disease Rat Model

ABSTRACT

The aim of the present study was to investigate the effects of treadmill exercise on neurogenesis (Ki-67), apoptosis (Bid, Bcl-xl), and spatial memory (Y-maze test) in the huntington's disease rat model. Forty male rats were divided into sham-operation group (n=10), sham-operation & treadmill exercise group (n=10), Huntington's disease group (n=10), and Huntington's disease & treadmill exercise group (n=10) at the age of 6 weeks. Rats in the treadmill exercise group performed treadmill exercises (5 days/week, 30 min/day) for 2 weeks. The present results found Huntington's disease & treadmill exercise group significantly enhanced hippocampal neurogenesis, apoptosis, and spatial memory compared to the Huntington's disease group (p<0.05). These results indicate that treadmill exercise improves brain functions of rats with Huntington’s disease.

Key words: Huntington's disease, treadmill exercise, neurogenesis, apoptosis, spatial memory