| 트레드밀 운동이 심근경색증 생쥐모델의 심기능 회복에 미치는 효과 |
| 김동환, 배혜란, 김미자, 소용석, 윤미연, 장성동, 김영준 |
| 동아대학교 |
| Effects of treadmill exercise on recovery of cardiac function in a mouse model of myocardial infarction |
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| ABSTRACT |
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The purpose of this study was to investigate the adequate intensity and the minimal duration of aerobic exercise to obtain the cardioprotective effect after myocardial infarction. Myocardial infarction model was established by occluding the left descending anterior artery in heart of CD 1 mice. Three days after myocardial infarction, mice were exercised with treadmill running with a speed of 8 m/min(low intensity), 12 m/min(moderate intensity) or 16 m/min(high intensity) at 10 degree incline 30 minutes per day for 8 weeks. Hematoxylin-eosin stain showed significant decrease in the size of infarct scar and increase in the thickness of normal myocardial tissue after 8 weeks of moderate intensity exercise. However, infarct scar was increased and further thinned after 8 weeks of high intensity exercise. Echocardiography revealed that both stroke volume and fractional shortening increased while both left ventricular internal diameter and endsystolic volume decreased after 8 weeks of moderate intensity exercise. Fractional ejection, a representative of cardiac function, was also increased. However, the echocardiographic parameters either became worse after 8 weeks of high intensity exercise or were not significant changed after 8 weeks of low intensity exercise. These results suggest that treadsmill exercise of moderate intensity at least for 8 weeks after myocardial infarction has beneficial effect in recovery of cardiac function in post-infarcted patients |
| Key words:
Myocardial infarction model, Treadmill exercise, Echocardiography, Infarct scar |
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