| 아동의 PPARGC1A 유전자형(Gly482Ser)과 신체활동, 비만지표, 대사성위험인자와의 연관성 |
| 안의수, 최규환, 조진경, 하창덕, 강현식 |
| 성균관대학교 |
| Relationships of the PPARGC1A genotypes with physical activity, body fatness and metabolic risk factors in children. |
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| ABSTRACT |
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The purpose of the study was to investigate the genetic effect of the PPARGC1A gene on body fatness and metabolic risk factors in Korean children. A single nucleotide polymorphism (SNP) of Gly482Ser(rs8192678) in the PPARGC1A gene was genotyped by using a Taqman assay in a total of 283 children (boys=150 & girls=133, aged 8 to 12 years) who were recruited from local elemental schools. Primary outcomes of the study included body composition parameters including weight, height, body mass index, waist circumference, percent body fat and waist-to-hip ratio and metabolic risk factors including resting blood pressures, triglycerides, total cholesterol, high-density lipoprotein cholesterol, fasting glucose, insulin and homeostasis assessment model of insulin resistance(HOMA-IR). One-way ANOVA followed by bonferroni post-hoc tests was used to test any significant associations between the measured variables and genotype at a statistical significance of p=.05. The Ser482Ser genotype had significantly higher values in body weight (p=.016), percent body fat (p=.009), hip (p=.038) and body mass index (p=.090) than either the Gly482Gly or Gly482Ser genotype. The findings of the study suggest that the Ser482Ser genotype might play as a predisposed risk for obesity in Korean children. |
| Key words:
Children, Gly482Ser SNP, Physical activity, Body Fatness, Metabolic Risk Factors |
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