| GABA가 함유된 클로렐라 섭취 및 자발적인 휠 달리기 운동이 자연발생고혈압쥐의 혈압, 주행량 및 항산화 효소에 미치는 영향 |
| 원상연, 김정수, 이미영, 오광훈 |
| 공주대학교 |
| The effect of GABA-enriched chlorella intake and voluntary wheel running on blood pressure, running distance and antioxidant enzyme in spontaneously hypertensive rats. |
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Published online: December 14, 2015. |
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| ABSTRACT |
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The purpose of this study was to investigate the effect of chlorella intake and voluntary wheel running on blood pressure, running distance and antioxidant enzyme in spontaneously hypertensive rats (SHR). Male SHR were divided into 4 groups：control(SHR-C), exercise(SHR-Ex), chlorella intake(SHR-CI) and chlrolella + exercise(SHR-CEx) at a 6 weeks of age respectively. SHR-CI and SHR-CEx were administered GABA during the experimental period(0.5mg/㎏/day). Exercised SHR were placed in cages with rotating wheels to allow voluntary running. Body weight, running distance, food consumption were measured every week. Blood pressure were measured every 2 weeks. After 12 weeks of feeding, values of antioxidant enzyme activity(superoxide dismutase；SOD, glutachion peroxidase；GPx, catalase；CAT) and malondialdehide(MDA) were measured on blood. The results were as follows. Blood pressure significantly decreased in SHR-CI and SHR-CEx(p<.01), and SHR-Ex lower than SHR-C(p<.01). Running distance significantly increased in SHR-CEx compared to SHR-Ex(p<.01). SOD and GPx were significantly elevated in SHR-Ex and SHR-CEx but CAT showed no changes. MDA was significantly decreased in SHR-Ex and SHR-CEx and increased in SHR-C and SHR-CI. These results suggest that the combined treatment of chlorella intake and voluntary exercise can reduce blood pressure and increase running distance and antioxidant enzyme in male SHR. |
| Key words:
Chlorella intake, Voluntary exercise, Blood pressure, Running distance, Antioxidant enzyme |
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