Mutation of β3-adrenergic receptor gene is associated with abdominal fat area and OGTT in Korean middle-aged women

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Exerc Sci > Volume 14(1); 2005 > Article

Exercise Science 2005;14(1): 1-10.

중년 여성의 베타-3 아드레날린 수용체 유전자 변이에 따른 복부지방면적 및 경구당 부하검사의 비교

김기진¹, 신윤정¹, 박주식², 홍창배¹, 안나영¹

¹계명대학교
²경주대학교

Mutation of β3-adrenergic receptor gene is associated with abdominal fat area and OGTT in Korean middle-aged women

ABSTRACT

Kim, K.J., Ahn, N.Y., Shin, Y.J., Park, J.S. Hong, C.G. Mutation of β3-adrenergic receptor gene is associated with abdominal fat area and OGTT in Korean middle-aged women. Exercise Science, 14(1): 1-10, 2005. To investigate whether a mutation in β3-adrenergic receptor gene may contribute to NIDDM prevalence, this study analyzed the differences of skinfold thickness, blood concentration of lipid profiles, abdominal fat area, and OGTT following to Trp64Arg polymorphism of β3-adrenergic receptor gene in Korean middle-aged women. The subjects were 32 Korean middle-aged women, and were divided to two groups as mutant β3-adrenergic receptor gene and normal homozygotes by PCR-RELP screening. The subjects with mutation showed a higher V/S ratio than subjects without mutation. But blood concentrations of glucose, FFA, lipid profiles, and insulin showed no significant differences. In OGTT test, the subjects with mutation showed trend to have higher blood glucose concentration, although blood insulin concentration was not significant differences between two groups. Therefore we could find a higher visceral fat area and glucose intolerance according to the Trp64Arg mutation of β3-adrenergic receptor gene, but it could not suggestion the critical results of insulin resistance.

Key words: obesity, visceral fat, OGTT, β3-adrenergic receptor gene