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Exercise Science 2007;16(2): 177-185. |
Endurance exercise enhances 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of 6-hydroxydopamine-induced Parkinson's rats |
김영표1, 신말순2, 윤진환3, 위승두4, 서영환4, 이희혁3, 천병옥2, 김창주2, 박후성4, 김홍2 |
1제주대학교 2경희대학교 3한남대학교 4조선대학교 |
Endurance exercise enhances 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of6-hydroxydopamine-induced Parkinson"s rats |
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ABSTRACT |
Park, H.S., Wee, S.D., Sea, Y.H., Lee, H.H., Yoon, J.H., Kim, H., Shin, M.S., Chun, B.O., Kim, C.J., Kim, Y.P. Endurance exercise enhances 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of 6-hydroxydopamine-induced Parkinson's rats. Exercise Science, 16(2): 177-185, 2007. In addition to the loss of dopamine neurons in Parkinson's disease, there are many evidences on the dysfunction of 5-hydroxytryptamine (serotonin) system and degeneration of 5-hydroxytryptamine neurons in the dorsal raphe. In the present study, we investigated the effect of treadmill exercise on the synthesis of 5-hydroxytryptamine and on the expression of tryptophan hydroxylase in the dorsal raphe by using immunohistochemistry. The lesion of nigrostriatal dopamine pathway in rats was made by unilaterally injection of 6-hydroxydopamine into the striatum. The rats in the exercise group were made to run on the treadmill for 30 minutes once a day during 14 consecutive days after 6-hydroxydopamine injection. Two weeks after injection of 6-hydroxydopamine, 5- hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe were decreased. It indicates that 6-hydroxydopamine- induced destruction of dopamine system in the striatum impaired serotonergic neural system in the dorsal raphe. However, treadmill running increased 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of 6-hydroxydopamine- injection rats. The present study revealed that endurance exercise is effective for the symptom improvement in Parkinson's disease patients.* This work was supported by the Korea Research Foundation Grant funded by the Korea Government (MOEHRD)(KRF-2005-041-G00120). |
Key words:
6-hydroxydopamine; Parkinson's disease; 5-hydroxytryptamine; Tryptophan hydroxylase; Dorsal raphe; Treadmill running |
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