| 정상체중아동과 비만아동의 인슐린저항성지표 및혈청 비스파틴 수준 비교 |
| 강현식, 하창덕, 정영훈, 홍혜련 |
| 성균관대학교 |
| Comparison of insulin resistance markers and serum visfatin levels between lean and obese children |
|
|
|
|
|
|
|
| ABSTRACT |
|
The purpose of this study was to compare insulin resistance markers and serum visfatin levels between normal weight and obese children. A total of 220 children (183 normal weight and 37 obese) aged 12-13 years were recruited from local elementary schools. Physical activities were objectively measured with an accelerometer for 7 consecutive days. Anthropometrics, blood pressure, lipids, glucose, insulin, and serum visfatin were measured following an overnight fast. Results showed：1) obese children had significantly higher values in Tanner scale(p=.004), body mass index(p<.001), percent body fat(p<.001), waist circumference(p<.001), waist-to-hip ratio(p<.001), systolic blood pressure(p<.001), and diastolic blood pressure(p<.001) than normal weight children; 2) obese children had significantly higher values in insulin(p<.001), homeostasis model of assessment for insulin resistance(p<.001), leptin(p<.001), and visfatin(p=.013) levels than normal weight children; and 3) obese children had significantly lower value in physical activity than normal weight children. Multivariate stepwise linear regression analysis showed that leptin(p=.003), HOMA-IR(p=.013), vigorous physical activity(p<.001), and caloric intake(p=.004) were significant predictors for serum visfatin levels in this study sample. The findings of the study suggest that increased vigorous physical activity along with healthy diets should be major targets of lifestyle interventions against insulin resistance and elevated serum visfatin levels in obese children. |
| Key words:
lean children, obese children, insulin resistance markers, serum visfatin levels |
|
|
|
PDF Links
Full text via DOI
Download Citation 
