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Exerc Sci > Volume 21(2); 2012 > Article
Exercise Science 2012;21(2): 201-212. doi: https://doi.org/10.15857/ksep.2012.21.2.201
16주 복합운동 프로그램이 중년 당뇨 여성의 혈중 지질과 미토콘드리아 DNA 손상에 미치는 영향
석민화, 신윤아
The effect of 16 weeks combined exercise training on lipid metabolism and DNA damage in middle-aged diabetic women
The purpose of this study was to compare to the different between diabetic middle-age women(n=25) and age-matched healthy women(n=31) on body composition, lipid profiles, and DNA damage factors. The comparison of control and diabetic were no significantly difference of weight, BMI, %fat, WHR, BP and V̇O2max. The diabetic group was significantly higher in TG(p<.01), glucose(p<.001), HOMA-IR(p<.05), 8-OHdG(p<.01) than control group. HDL-C(p<.01),SOD(p<.05), mtDNA contents(p<.05) were significantly lower in diabetic group. We also studied about the middle-aged women with diabetes(n=8) and age-matched healthy controls(n=10) after 16 weeks combined exercise training. Weight(p<.001), BMI(p<.01),%fat(p<.01), WHR(p<.001), DBP(p<.05), glucose(p<.01) and HOMA-IR(p<.05) were significantly decreased after exercise training, and there was significantly different between groups in HDL(p<.05), TG(p<.01), glucose(p<.001), and SOD(p<.01). 8-OHdG was significantly decreased in diabetic group(p<.05), but mtDNA contents was increased but not significantly different. It was concluded that DNA damage was higher in diabetic group, however, after 16weeks combined exercise training, insulin resistance, 8-OHdG were decreased, and SOD was increased in diabetic group. In conclusion, the present study demonstrated
Key words: Diatetic women, SOD, MDA, 8-OHdG, Mitochindria DNA
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