Effects of enriched environment including voluntary wheel running on short？erm memory and neurogenesis in the hippocampal dentate gyrus of mice with streptozotocin？nduced diabetes

,; ,; ,; ,; ,; ,; ,; ,; ,; ,

Exerc Sci > Volume 15(3); 2006 > Article

Exercise Science 2006;15(3): 259-268.

자발적 휠 달리기를 포함한 enriched 환경이 streptozotocin에 의해 유발된 당뇨 쥐 해마의 신경세포생성과 단기기억력에 미치는 효과

백성수¹, 김유미², 김창주³, 주광중⁴, 고일규³

¹서울대학교
²고려대학교
³경희대학교
⁴성균관대학교

Effects of enriched environment including voluntary wheel running on short？erm memory and neurogenesis in the hippocampal dentate gyrus of mice with streptozotocin？nduced diabetes

ABSTRACT

Baek, S.S., Kim, Y.M., Joo, K.J., Ko, I.G., Kim, C.J. Effects of enriched environment including voluntary wheel running on short-term memory and neurogenesis in the hippocampal dentate gyrus of mice with streptozotocin-induced diabetes. Exercise Science. 15(3): 259-268, 2006. Exposure to an enriched environment and physical activity, such as voluntary running, increases neurogenesis of granule cells in the dentate gyrus of mice. Diabetes mellitus is one of the most common metabolic disorders in humans. In the present study, the effects of enriched environment including voluntary wheel running on short-term memory and neurogenesis in the hippocampal dentate gyrus of the mice with streptozotocin(STZ)-induced diabetes was investigated via step-down avoidance task and 5-bromo- 2'-deoxyuridine(BrdU)-specific immunohistochemistry. Male IRC mice were randomly divided into the four groups: the control group, the STZ-induced diabetes group, STZ-induced diabetes with voluntary wheel running group, and the STZ-induced diabetes with enriched environment including voluntary wheel running group. The mice in all of the groups were intraperitoneally injected with 50 mg/kg BrdU once a day for 4 weeks. In the present results, the STZ-induced diabetic mice showed decreased neurogenesis in the hippocampal dentate gyrus, whereas exposure to enriched environment including voluntary wheel running increased neurogenesis in the STZ-induced diabetic mice. The latency in the STZ-induced diabetes group was shorter than the control group. Enriched environment including voluntary wheel running exceedingly delayed the latency of mice in the STZ-induced diabetic groups. Therefore, it can be suggested that enriched environment including voluntary wheel running may enhance brain function via increasing neurogenesis in the diabetic patients.

Key words: voluntary wheel running, enriched environment, diabetes, short-term memory, neurogenesis