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Exerc Sci > Volume 24(1); 2015 > Article
Exercise Science 2015;24(1): 49-58. doi: https://doi.org/10.15857/ksep.2015.24.1.49
PPARδ의 활성 또는 과발현은 PGC-1α 단백질의 분해를 지연시킨다
고진호1, 김홍수2, 안나영1, 김기진1
1계명대학교
2계명문화대학
PPARδ activation or overexpression attenuates PGC-1α protein degradation
ABSTRACT
"PURPOSE:
The purpose of this study was to evaluate whether PPARδattenuates PGC-1α protein degradation in mouse skeletal muscle after a single bout of swimming exercise (Ex).
METHODS:
PPARδactivation in mouse skeletal muscle was achieved by high fat diet (HFD) for 2 weeks. PPARδoverexpression in mouse skeletal muscle was achieved by electroporation(EPO). To evaluate PGC-1α, cytochrome c oxidase subunit Ⅳ (COXⅣ) and succinate-ubiquinone oxidoreductase (SUO) protein in mouse skeletal muscle, tibialis anterior (TA) muscle were dissected at 24 h or 54 h after a single bout of swimming exercise.
RESULTS:
PGC-1α and mitochondrial enzyme in all exercised muscle were significantly increased by a single bout of swimming exercise when compare to non-exercised muscle. PGC-1α expression in 54 h post-Ex Chow group was decreased 60% when compare to 24 h post-Ex Chow group, but 54 h post-Ex HFD group was not significantly decrease when compare to 24 h post-Ex HFD. PGC-1αexpression in 54 h post-Ex HFD group was higher 1.4 fold than 54 h post-Ex Chow group. PGC-1α expression in 54 h post-Ex EV group was decreased 75% when compare to 24 h post-Ex Ev group, but 54 h post-Ex PPARδ group was decrease 1% when compare to 24 h post-Ex PPARδ. PGC-1α expression in 54 h post-Ex PPARδ group was 1.9 fold higher than 54 h post-Ex EV group. COXⅣ와 SUO expression in 54 h post-Ex PPARδ group were 1.4 and 1.94 fold higher than 54 h post-Ex EV group.
CONCLUSIONS:
This study demonstrated that PPARδ activation or overexpression attenuate PGC-1α protein degradation in skeletal muscle after a single bout of swimming exercise that causes a more increase mitochondrial biogenesis."
Key words: Endurance exercise, PPARδ, PGC-1α, mitochondrial enzymes
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