| 항산화제 처치와 단기간의 지구성 운동이 골격근의 인슐린 유발 포도당 이동률에 미치는 영향 |
| 정수련 |
| 경주대학교 |
| The effects of antioxidants treatment on training induced insulin-stimulated glucose transport activity in muscle. |
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| ABSTRACT |
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The objectives of this study were to determine whether antioxidants treatment decrease training induced insulin-stimulated glucose transport activity and block GLUT4 biogenesis in muscle. 24 male Wistar rats were randomly assigned into 4 groups(Sedentary, Sedentary/Antioxidant, Exercise, Exercise/Antioxidant treat group). Antioxidants were given orally for a week, and for the control groups, same volume of vehicle was orally provided. After a week with or without antioxidants treatment, the two exercise-groups were trained by using 6h/day, 3-day-long swimming program. Swimming training increased GLUT4 protein concentration and insulin responsiveness by 76% and 123%, respectively, relative to sedentary groups(p<0.05). However, antioxidants treatment did not change GLUT4 protein contents or the insulin stimulated-glucose transport activities on either exercise group or sedentary group. The COX IV protein concentration was significantly increased by 3d-swimming exercise, but antioxidants treatment did not change COX IV protein contents. We concluded that antioxidants treatment do not prevent endurance training induced increase in skeletal muscle insulin responsiveness. |
| Key words:
antioxidant, endurance exercise, insulin responsiveness, GLUT4, COX IV |
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