Effects of diverse exercise Intensities on levels of MDA, SOD, GPx, and TNF-α in human plasma

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doi:2009.18.1.1

Exerc Sci > Volume 18(1); 2009 > Article

Exercise Science 2009;18(1): 1-10. doi: https://doi.org/10.15857/ksep.2009.18.1.1

다양한 운동강도가 혈장 지질과산화물, 항산화효소 및 염증성 사이토카인에 미치는 영향

김시영¹, 송욱²

¹세종대학교
²서울대학교

Effects of diverse exercise Intensities on levels of MDA, SOD, GPx, and TNF-α in human plasma

ABSTRACT

We investigated the effects of diverse exercise intensities on levels of MDA, SOD, GPx, and TNF-α in human plasma. Twelve volunteers participated in the exercise program which consisted of four intensities [40, 60, 80, and 100% of heart rate reserve(HRR)] on the treadmill and resting conditions. To determine whether levels of MDA, SOD, GPx, and TNF-α are dependent on exercise intensity, we used commercial assay kits, respectively using isolated human plasma, collected immediately after exercise. As exercise intensity increases, the levels of MDA(p<.05) and SOD(p<.05) decreased to 60% HRR and 80% HRR respectively, and then continuously increased to 100% HRR. In addition, GPx level increased in proportion to the exercise intensity (p<.05), whereas TNF-α level was not changed significantly. In conclusion, the exercise-induced changes of MDA, SOD, and GPx levels in human plasma appears to be attributed to the physiological adaptation to lower exercise intensity and increased oxidative stress as a consequence of higher oxygen consumption.

Key words: exercise intensity, human plasma, MDA, SOD, GPx, TNF-α