| 트레드밀 운동이 ICV-STZ 처치 흰쥐의 뇌 인슐린 신호전달, 포도당 대사 및 Tau 단백질 과인산화에 미치는 영향 |
| 강은범1, 김창환2, 조준용1 |
1한국체육대학교
2대전대학교 |
| Effects of Treadmill Exercise on Brain Insulin Signaling, Glucose Metabolism and Tau Hyperphosphorylation in Intracerebroventricular Streptozotocin Induced-Memory Impairment in Rats |
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| ABSTRACT |
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The purpose of this study was to explore the effect of 6-week treadmill exercise on brain insulin signaling, glucose metabolism and hyperphosphorylation of Tau protein in Alzheimer dementia rats induced by intracerebroventricular (ICV) treatment of streptozotocin (STZ). To produce Alzheimer animal model, STZ (1.5 mg/kg) was injected in both cerebral ventricles of 20-week Sprague-Dawley rats, which were classified into ICV-Sham, ICV-STZ CON and ICV-STZ TE (treadmill exercise). Treadmill exercises were conducted for 30 minutes a day, 5 days a week and for the duration of 6 weeks. Water maze tests were performed before and after the treadmill exercises. Time and distance of escape significantly increased in ICV-STZ CON group compared with those in ICV-Sham group. Nevertheless, time and distance of escape significantly decreased in ICV-STZ TE group with 6-week treadmill exercise compared with those in ICV-STZ CON group. The treatment of ICV-STZ increased hyperphosphorylation of Tau protein and decreased the activity of brain insulin signaling in cerebral hippocampus of rats. Yet, hyperphosphorylation of Tau protein decreased more in ICV-STZ TE group, for which treadmill exercise were administered, than in ICV-STZ CON group while the activity of proteins related to brain insulin signaling (IR, PI3K, AKT) increased. In addition, phosphorylation of GSK3β, a major kinase of Tau protein, increased which resulted in the decrease of activity. Although both GLUT1 and GLUT3, glucose transporters in brain, decreased expression in hippocampus, treadmill exercise increased utilization efficiency of glucose in the brain. Treadmill exercise suppressed hyperphosphorylation of Tau protein, a component of neurofibrillary tangle, and resulted in the enhancement of perceptive ability. In conclusion, aerobic exercise can be administered as an effective alternative in the prevention and treatment of Alzheimer's disease. |
| Key words:
Alzheimer’s disease, treadmill exericse, insuin signaling, glucose metabolism, Tau |
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