| 6주 분할운동이 노화된 흰쥐 골격근 내 자식작용과 근육형성조절인자의 발현에 미치는 영향 |
| 김정석 |
| 전북대학교 |
| Effect of 6-week Multiple Short-Duration Exercise Training on the Expression of Autophagic Markers and Myogenesis Regulatory Factors in Aged Rat Skeletal Muscle |
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| ABSTRACT |
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The aim of this study was to investigate effect of 6-week multiple short-duration exercise training on the expression of autophagic markers and myogenesis regulatory factors in skeletal muscle of Sprague-Dawley aged rats during intensive endurance exercise(16 m/min, 5°, 3×10 min/day, 5 day/week, 6 weeks). The expression of Atg5, Beclin-1, LC3-Ⅱ, AMPK, FoxO1, mTOR, MyoD, Myogenin proteins in skeletal muscle was analyzed by Western blotting. The expression of Atg5 and Beclin-1 proteins was significantly increased due to the multiple short-duration exercise in the aged rats. LC3-Ⅱ protein, however, was not significantly decreased in the exercise group. AMPK and FoxO1 proteins were significantly increased in the exercise group. In contrast, mTOR protein was not significantly decreased in the exercise group. In addition, MyoD and Myogenin proteins were significantly increased in the exercise group. These findings suggest that the expression of the autophagic markers and myogenesis regulatory factors plays a role in the maintenance of homeostasis in aging skeletal muscle during multiple short-duration exercise training. |
| Key words:
aging, multiple short-duration exercise, autophagic markers, myogenesis regulatory factors |
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