| 운동이 중년여성 말초단핵구세포의 reverse cholesterol transport pathway 유전자 발현에 미치는 영향 |
| 조진경1, 김영민1, 진영윤2, 하창덕1, 최규환1, 홍혜련1, 이신호1, 강현식1 |
1성균관대학교
2국민체육진흥공단체육과학연구원 |
| Effects of Exercise on Genes Expression of the Reverse Cholesterol Transport Pathway in Middle-Aged Women. |
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| ABSTRACT |
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The purpose of the present study was to investigate the effects of both acute exercise and exercise training on blood lipids and mRNAs expression of RCT pathway in middle-aged women (n=8). In a single-group cross-over design, subjects performed a 3-day consecutive exercise at an intensity of 65% VO2max targeting at energy expenditure of 1,200 kcal (400 kcal/day) and a 3-day control period. And they were further asked to participate in a 4-week exercise training at the same intensity of 65% VO2max with a frequency of 3 days per week. The measured outcomes of the study included body composition (i.e., weight, body mass index, body fat, waist circumference), blood lipoprotein lipids (i.e., triglycerides, total cholesterol, high-density lipoprotein cholesterol, apolipoprotein A-1) and RCT pathway mRNAs (i.e., ABCA1 mRNA, ABCG1 mRNA, SR-B1 mRNA) in peripheral blood mononuclear cells (PBMC). One-way RM ANOVA followed by LSD post-hoc and paired t-test were utilized to test any significant changes in the outcomes of the acute exercise and exercise training, respectively. The findings of the study showed that 1) acute exercise induced a significant decrease in serum triglycerides, with no other significant changes in any of the measured variables and 2) unlike acute exercise, exercise training resulted in significant increases in high-density lipoprotein cholesterol and apolipoprotein A-1 as well as a significant increase in PBMC ABCG1 mRNA. In summary, the current findings of the study suggest that aerobic exercise training can contribute to improved RCT pathway functioning in middle-aged women as shown in increases in HDLC, apoA-1, and ABCG1 mRNA. |
| Key words:
Exercise training, RCT pathway, High-density lipoprotein cholesterol, Apolipoprotein A-1 |
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